Carbon baby syndrome: two case reports

Carbon baby syndrome, also known as universal acquired melanosis is one of the causes of diffuse hyperpigmentation of skin and mucosa with only a limited number of reported cases in the literature. We here report, two cases of universal acquired melanosis in two siblings of a family. They developed progressive darkening of skin and mucosa from 5 and 4 months of their lives, respectively. The colour change was insidious, asymptomatic, progressive and generalised. Histopathology showed increased pigmentation of epidermal basal layer. According to clinicohistological assessment, the cases were diagnosed as carbon baby syndrome with familial clustering

Extramammary Paget's disease: presenting in an unusual site

Extramammary Paget's disease [EMPD] is a rare neoplasm with only a limited number of reported cases in literature. It is mainly composed of intraepidermal Paget cells and possesses variable clinical behaviour and histological appearance leading to difficulty in diagnosis. We here report a case of primary EMPD in a 71-year-old male who presented with gradually progressive, pruritic, eczematous lesion in suprapubic region, not responding to topical medications. Histological assessment showed Paget cells infiltration throughout the epidermis with dermal invasion. Using immunohistochemistry, the expression of CK7, carcinoembryonic antigen [CEA] was examined to elucidate cellular differentiation of the carcinoma

Metastatic adenocarcinoma of unknown primary origin

Cancer of unknown primary [CUP] origin is the diagnosis when metastatic cancer is found but the primary site cannot be determined. The peculiarity of our case is eleven months after the occurrence of two lesions of florid cutaneous metastases, the primary tumor or metastasis to a second organ could still not be identified despite thorough investigation